منابع مشابه
Lung capillaries raise the hypoxia alarm.
When ventilation is blocked, the lung can protect against the loss of blood oxygenation by activating localized arterial vasoconstriction, reducing blood flow to underventilated regions, and redirecting flow to better-ventilated alveoli. This phenomenon, hypoxic pulmonary vasoconstriction (HPV), preserves the overall efficiency of blood oxygenation, but the mechanism by which the hypoxic signal...
متن کاملIncreased brain capillaries in chronic hypoxia.
The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels was studied in Balb/c mice. In comparison to age-matched controls kept at sea level, emulsion-perfused capillaries in hypoxic mice showed marked dilation in all brain areas studied. Capillary length per unit volume of tissue (Lv) was increased in the cerebellar granular layer, the caudate nucleus, t...
متن کاملThe Role of Anion Exchanger on Pulmonary Vascular Response to Sustained Alveolar Hypoxia in the Isolated Perfused Rabbit Lung
Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...
متن کاملMechanotransduction in the Lung Pressure-induced endothelial Ca oscillations in lung capillaries
Kuebler, Wolfgang M., Xiaoyou Ying, and Jahar Bhattacharya. Pressure-induced endothelial Ca2 oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol 282: L917–L923, 2002; 10.1152/ajplung.00275.2001.—Endothelial second messenger responses may contribute to the pathology of high vascular pressure but remain poorly understood because of the lack of direct in situ quantification. In lu...
متن کاملUltrastructure of the lung in chronic hypoxia.
The most striking changes in the lungs in response to prolonged alveolar hypoxia occur in the small pulmonary arteries and arterioles. The influence ofchronic hypoxia on these small vessels has been subjected to extensive physiological investigation and to pathological examination by light and electron microscopy. The lung parenchyma, too, may be modified, but usually in response to brief sever...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2012
ISSN: 0021-9738
DOI: 10.1172/jci65623